A pharmacist has warned people taking omeprazole for acid reflux to watch out for symptoms that could signal a worrying side effect. Raj Patel, known as the Straight-Talking Pharmacist on TikTok, where he has more than 100,000 followers, issued the warning in a video about long-term use of the medication.
Omeprazole belongs to a group of medicines called proton pump inhibitors (PPIs), which work by reducing the amount of acid produced in the stomach. It is commonly prescribed for conditions including heartburn and acid reflux, and some people need to take it for months or years.
In his video, Mr Patel said: “Long term omeprazole use can lead to a drop in magnesium levels. This isn’t just a minor issue, it can make you feel tired, confused and dizzy.”
The warning is backed by UK medicines guidance, which says low magnesium has been reported in some people taking PPIs for three months or longer, although most reported cases occurred after a year of treatment. The Medicines and Healthcare products Regulatory Agency (MHRA) says symptoms can develop gradually and may be overlooked.
Other signs can include muscle twitches, tremors and an irregular heartbeat, according to the regulator. Mr Patel also highlighted these symptoms, saying they are “even more concerning”.
The pharmacist also drew attention to possible vitamin B12 deficiency, which can be associated with long-term use of medicines that reduce stomach acid. He said: “Vitamin B12 deficiency is another silent attacker, creeping in with symptoms like extreme fatigue, a sore and red tongue, mouth ulcers and that unsettling feeling of pins and needles.”
Other potential concerns linked with prolonged PPI use include gut infections and an increased risk of bone fractures, particularly among people who already have risk factors such as osteoporosis. Evidence about long-term risks varies, and reports of a possible link between PPIs and stomach cancer do not establish that the medicine causes the disease.
People taking omeprazole should not panic or stop their medication without medical advice, as it may be needed to control their condition. Anyone who has been taking it long term and develops symptoms that concern them should speak to their GP, who can review treatment and decide whether checks, including a blood test for magnesium, are appropriate.