The announcement was made on Tuesday by The CW and CBS Television as well as the star.
‘Working on the Dynasty reboot and reprising the iconic role of Alexis has been thoroughly enjoyable, but the chance to spend precious time with my terminally ill mother is more important to me right now,’ the Hollywood vet said to TV Line.
The 55-year-old actress will be tending to her 72-year-old mother Sally Sheridan who has been ill.
She added, ‘I am profoundly grateful to Mark Pedowitz (The CW) and David Stapf (CBS) for graciously allowing me to return to Los Angeles to be with her, and I wish them and everyone associated with the show nothing but continued success.
‘I am hopeful that my fans will embrace my successor with as much passion as they embraced me.’
The CW and CBS said: ‘Nicollette Sheridan will be leaving Dynasty in order to focus on some personal family responsibilities. She was a valuable asset to the show and we wish her continued success in the future.’
Here is a List of 7 series’ you must watch before May ends…thank me later
The blonde beauty played Alexis Carrington, a role that was originated in the 1980s by iconic actress Joan Collins.
It is not known who will next play Alexis though Dynasty has already been renewed for a third season at The CW.